USP6 Gene Summary [Human]
Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination and regulation of vesicle-mediated transport. Located in plasma membrane and recycling endosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | USP6 |
| Official Name | ubiquitin specific peptidase 6 [Source:HGNC Symbol;Acc:HGNC:12629] |
| Ensembl ID | ENSG00000129204 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 6, ubiquitin carboxyl-terminal hydrolase 6, TBC1D3 and USP32 fusion, Tre-2 oncogene |
| Synonyms | HRP1, TRE17, TRE2, TRESMCR, ubiquitin specific peptidase 6, USP6-short |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- cysteine endopeptidase
- nucleic acid binding
- peptidase
- Domain in Tre-2, BUB2p, and Cdc16p
- ubiquitin-specific protease
- protein binding
Pathways
Biological processes and signaling networks where the USP6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- hemimegalencephaly
- chronic myeloid leukemia
- infection by HIV-1
role in cell
- expression in
- apoptosis
- phosphorylation in
- activation in
- accumulation in
- stabilization in
- deubiquitination in
- decline in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- insoluble fractions
- glutaminergic synapse
- organelle
- filamentous network
- Plasma Membrane
- lysosome
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- protein modification process
- proteolysis
- regulation of vesicle-mediated transport
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- Golgi apparatus
- recycling endosome
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- ubiquitin-specific protease activity
- calmodulin binding
- protein binding
- cysteine-type endopeptidase activity