LSP1 Gene Summary [Human]
This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LSP1 |
| Official Name | lymphocyte specific protein 1 [Source:HGNC Symbol;Acc:HGNC:6707] |
| Ensembl ID | ENSG00000130592 |
| Bio databases IDs | |
| Aliases | lymphocyte specific protein 1 |
| Synonyms | Calcium-binding Protein pp52, lymphocyte specific 1, lymphocyte-specific protein 1, p50, pp52, WP34 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LSP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- caldesmon-like domain
- actin binding
- villin-like domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bladder cancer
- cardiovascular disorder
- hypertension
- essential hypertension
- ulcerative colitis
- milk allergy
- major depression
- breast carcinoma
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- number
- apoptosis
- quantity
- expression in
- recruitment
- migration
- morphology
- transendothelial migration
- motility
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- cytosol
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LSP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- cellular defense response
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- actin cytoskeleton
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding