NR1H2 Gene Summary [Human]
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | NR1H2 |
| Official Name | nuclear receptor subfamily 1 group H member 2 [Source:HGNC Symbol;Acc:HGNC:7965] |
| Ensembl ID | ENSG00000131408 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 1 group H member 2, liver X receptor-beta |
| Synonyms | Liver X receptor, LXR, LXR-b, LXRbeta, LXRBSV, Lxr β, NER, NER1, NER-I, nuclear receptor subfamily 1 group H member 2, nuclear receptor subfamily 1, group H, member 2, OR-1, Retinoid x receptor interacting, RIP15, UNR, Unr2, UR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NR1H2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- DNA binding domain
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- nucleic acid binding
- alpha helix
- AF-2 transcription activation domain
- chromatin binding
- protein binding
- receptor binding
- sequence-specific DNA binding
- DNA binding
- PEST domain
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- ATPase binding
- ligand-binding domain
- double-stranded DNA binding
- ligand-dependent nuclear receptor
- retinoid X receptor binding
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the NR1H2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- epithelial neoplasia
- epithelial cancer
- cancer
- COVID-19
- polydipsia
- lymphoid hyperplasia
- preeclampsia
- squamous cell lung cancer
- dyslipidemia
role in cell
- expression in
- proliferation
- migration
- size
- senescence
- activation
- apoptosis
- growth
- accumulation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NR1H2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylcholine acyl-chain remodeling
- negative regulation of proteolysis
- positive regulation of transcription from RNA polymerase II promoter
- cholesterol homeostasis
- positive regulation of fatty acid biosynthetic process
- hormone-mediated signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of protein metabolic process
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of cholesterol efflux
- positive regulation of lipoprotein lipase activity
- intracellular receptor mediated signaling pathway
- negative regulation of lipid transport
- mRNA transcription from RNA polymerase II promoter
- positive regulation of secretion of lysosomal enzymes
- positive regulation of pancreatic juice secretion
- negative regulation of interferon-gamma-mediated signaling pathway
- negative regulation of pinocytosis
- positive regulation of triglyceride biosynthetic process
- cell differentiation
- negative regulation of macrophage derived foam cell differentiation
- positive regulation of cholesterol transport
- negative regulation of cholesterol storage
- positive regulation of lipid storage
- positive regulation of high-density lipoprotein particle assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- chromatin DNA binding
- zinc ion binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- apolipoprotein A-I receptor binding
- retinoid X receptor binding
- ATPase binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity