TNS4 Gene Summary [Human]
Predicted to enable actin binding activity. Involved in protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | TNS4 |
| Official Name | tensin 4 [Source:HGNC Symbol;Acc:HGNC:24352] |
| Ensembl ID | ENSG00000131746 |
| Bio databases IDs | |
| Aliases | tensin 4, C terminal tensin like |
| Synonyms | 9930017A07Rik, AA589547, CTEN, PP14434, RGD1310402, tensin 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNS4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Src homology 2 (SH2) domain
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- non-small cell lung cancer
- pneumonia
- colon cancer
- diabetic nephropathy
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- pancreatic carcinoma
role in cell
- apoptosis
- formation
- formation in
- colony formation
- ubiquitination in
- growth
- migration
- adhesion
- invasion
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNS4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- focal adhesion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding