ILKAP Gene Summary [Human]
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | ILKAP |
| Official Name | ILK associated serine/threonine phosphatase [Source:HGNC Symbol;Acc:HGNC:15566] |
| Ensembl ID | ENSG00000132323 |
| Bio databases IDs | |
| Aliases | ILK associated serine/threonine phosphatase, protein phosphatase, Mg2+/Mn2+ dependent 1O |
| Synonyms | 0710007A14RIK, 1600009O09Rik, AF095927, AK055417, ILKAP2, ILKAP3, ILK associated serine/threonine phosphatase, integrin-linked kinase-associated serine/threonine phosphatase 2C, PP2C-D, PP2C-DELTA, PP2C-δ, PPM1O |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ILKAP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein phosphatase 2C
- catalytic domain
- protein serine/threonine phosphatase
- phosphatase
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- PP2Cc
Pathways
Biological processes and signaling networks where the ILKAP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- Alzheimer disease
- breast cancer
- chronic lymphocytic leukemia
role in cell
- expression in
- activation in
- apoptosis
- phosphorylation in
- growth
- binding in
- differentiation
- size
- glycolysis in
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ILKAP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- myosin phosphatase activity