Prmt7 Gene Summary [Mouse]
Enables histone H4R3 methyltransferase activity and protein-arginine omega-N symmetric methyltransferase activity. Involved in genomic imprinting. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human PRMT7 (protein arginine methyltransferase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prmt7 |
| Official Name | protein arginine N-methyltransferase 7 [Source:MGI Symbol;Acc:MGI:2384879] |
| Ensembl ID | ENSMUSG00000060098 |
| Bio databases IDs | |
| Aliases | protein arginine N-methyltransferase 7 |
| Synonyms | 4933402B05Rik, protein arginine methyltransferase 7, protein arginine N-methyltransferase 7, RGD1304869, SBIDDS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prmt7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- histone methyltransferase
- ribonucleoprotein binding
- enzyme
- protein binding
- protein-arginine N-methyltransferase
- S-adenosylmethionine-dependent methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- prostate cancer
- epithelial cancer
- short stature, brachydactyly, intellectual developmental disability, and seizures
- hereditary disorder
- hepatocellular carcinoma
- liver cancer
- colorectal cancer
- fibrosis
regulated by
- AGT
- 293t cells
- 293 cells
role in cell
- expression in
- proliferation
- migration
- colony formation
- quantity
- formation
- number
- formation in
- G1 phase
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prmt7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- regulation of protein binding
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
- genetic imprinting
- spliceosomal snRNP assembly
- peptidyl-arginine methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein-arginine omega-N symmetric methyltransferase activity
- protein binding
- histone binding
- histone methyltransferase activity (H4-R3 specific)
- ribonucleoprotein complex binding
- histone methyltransferase activity
- protein-arginine omega-N monomethyltransferase activity
- protein-arginine N-methyltransferase activity
- S-adenosylmethionine-dependent methyltransferase activity