PIK3CG
PIK3CG Gene Summary
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]
Details
| Type | Protein Coding |
| Official Symbol | PIK3CG |
| Official Name | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:8978] |
| Ensembl ID | ENSG00000105851 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma |
| Synonyms | 5830428L06Rik,IMD97,IP3-gamma,IP3-γ,p110gamma,P110-γ,p120-PI3K,phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma,phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma,phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ,phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit γ,PI3CG,PI3K,PI3K CS,PI3Kgamma,PI3Kγ,PIK3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase
- PIK3 catalytic subunit gamma adaptor-binding domain
- Phosphatidylinositol 3- and 4-kinase
- catalytic domain
- ATP-binding domain
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- ephrin receptor binding
- protein binding
- PI3-kinase family, ras-binding domain
- identical protein binding
- PI3Ka
- kinase
- kinase domain
- phosphatidylinositol 3-kinase
- phosphatidylinositol-4-phosphate 3-kinase
- Phosphoinositide 3-kinase, catalytic domain
- Protein Kinases, catalytic domain
- Ras-binding domain
- C2 domain
Pathways
Biological processes and signaling networks where the PIK3CG gene plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Cancer Drug Resistance By Drug Efflux
- CCR3 Signaling in Eosinophils
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- EGF Signaling
- ErbB Signaling
- ErbB4 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- MSP-RON Signaling Pathway
- Neurotrophin/TRK Signaling
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th2 Pathway
- Thyroid Cancer Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SYK
- WIPF1
- G protein beta gamma core
- USP45
- ZAP70
- CD44
- PIK3R5
- PRKCZ
- PIK3R6
- PDE3B
disease
- metastatic breast cancer
- neoplasia
- postmenopausal breast cancer
- hypertension
- epithelial cancer
- epithelial neoplasia
- cancer
- pancreatic neoplasia
- breast adenocarcinoma
- breast carcinoma
regulated by
- cholesterol
- PTGS2
- TNF
- CSF2
- CD28
- lipopolysaccharide
- TCR (complex)
- tretinoin
- CCL5
- NLRX1
regulates
- IL6
- reactive oxygen species
- CTSK
- RELA
- CCL2
- IL1B
- NOS2
- CSF2
- NFkB (complex)
- ICAM1
role in cell
- production in
- generation in
- expression in
- phosphorylation in
- apoptosis
- cellular infiltration by
- survival
- proliferation
- quantity
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PIK3CG gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- positive regulation of Rac protein signal transduction
- secretory granule localization
- T cell activation
- phosphatidylinositol-3-phosphate biosynthetic process
- phosphatidylinositol phosphorylation
- regulation of angiogenesis
- mast cell degranulation
- sphingosine-1-phosphate signaling pathway
- positive regulation of acute inflammatory response
- protein kinase B signaling cascade
- inflammatory response
- immune response
- T cell chemotaxis
- respiratory burst involved in defense response
- angiogenesis
- negative regulation of triglyceride catabolic process
- phosphorylation
- platelet aggregation
- positive regulation of endothelial cell migration
- cell migration
- negative regulation of fibroblast apoptotic process
- G-protein coupled receptor signaling pathway
- adaptive immune response
- phospholipase C-activating G-protein coupled receptor signaling pathway
- endocytosis
- elevation of cytosolic calcium ion concentration
- hepatocyte apoptotic process
- regulation of cell adhesion mediated by integrin
- phosphatidylinositol-mediated signaling
- innate immune response
- neutrophil extravasation
- T cell proliferation
- dendritic cell chemotaxis
- cellular response to cAMP
- neutrophil chemotaxis
- natural killer cell chemotaxis
- positive regulation of cytokine production
- positive regulation of protein kinase B signaling cascade
- negative regulation of cardiac muscle contraction
CELLULAR COMPONENT
Where in the cell the gene product is active
- 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
- 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
- cytoplasm
- membrane
- cytosol
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- ephrin receptor binding
- protein kinase activity
- protein serine/threonine kinase activity
- phosphatidylinositol-4,5-bisphosphate 3-kinase activity
- kinase activity
- 1-phosphatidylinositol-4-phosphate 3-kinase activity
- 1-phosphatidylinositol-3-kinase activity