ING1 Gene Summary [Human]
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ING1 |
| Official Name | inhibitor of growth family member 1 [Source:HGNC Symbol;Acc:HGNC:6062] |
| Ensembl ID | ENSG00000153487 |
| Bio databases IDs | |
| Aliases | inhibitor of growth family member 1, inhibitor of growth 1, tumor suppressor ING1, growth inhibitor ING1, growth inhibitory protein ING1 |
| Synonyms | 2610028J21Rik, Ingh, inhibitor of growth family member 1, inhibitor of growth family, member 1, mING1h, p33ING1, p33ING1b, p33ING1c, p37Ing1b |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ING1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone binding
- transcription regulator
- PCNA-interacting protein box
- protein binding activity, bridging
- PHD finger superfamily
- Inhibitor of growth (ING) domain family
- protein binding
- zinc finger domain
- SAP30 binding domain
- Inhibitor of growth proteins N-terminal histone-binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- hepatocellular carcinoma
- colorectal cancer
- liver cancer
- epithelial cancer
- cancer
- adenocarcinoma
- squamous cell cancer
- head and neck squamous cell cancer
- head and neck cancer
role in cell
- cell cycle progression
- colony formation
- proliferation
- apoptosis
- expression in
- growth
- survival
- cytostasis
- binding
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- centromeric region
- nuclear foci
- heterochromatic compartments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ING1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of cell growth
- positive regulation of transcription, DNA-dependent
- protein import into nucleus
- negative regulation of cell proliferation
- regulation of programmed cell death
- negative regulation of cell migration
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- methylated histone residue binding