AGO4 Gene Summary [Human]
This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | AGO4 |
| Official Name | argonaute RISC component 4 [Source:HGNC Symbol;Acc:HGNC:18424] |
| Ensembl ID | ENSG00000134698 |
| Bio databases IDs | |
| Aliases | argonaute RISC component 4, argonaute 4 |
| Synonyms | 5730550L01Rik, argonaute RISC catalytic subunit 4, argonaute RISC component 4, EIF2C4, LOC102554576 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGO4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Piwi-like
- Argonaute linker 2 domain
- N-terminal domain of argonaute
- PAZ domain
- protein binding
- single-stranded RNA binding
- Piwi domain
- translation regulator
- RNA binding
- Mid domain of argonaute
- Argonaute linker 1 domain
- double-stranded RNA binding
- PAZ
Pathways
Biological processes and signaling networks where the AGO4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- squamous cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- oligozoospermia
- lung squamous cell carcinoma
- schizophrenia
role in cell
- growth
- phosphorylation in
- expression in
- apoptosis
- migration
- formation
- proliferation
- differentiation
- meiosis
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- GW body
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGO4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translation involved in gene silencing by miRNA
- male gonad development
- regulation of cell morphogenesis
- posttranscriptional gene silencing by RNA
- pre-miRNA processing
- male meiosis
- production of miRNAs involved in gene silencing by miRNA
- synaptonemal complex assembly
- mRNA catabolic process
- negative regulation of apoptotic process
- RNA secondary structure unwinding
- mRNA cleavage involved in gene silencing by miRNA
- small RNA loading onto RISC
- miRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- cytoplasmic mRNA processing body
- RISC-loading complex
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- protein binding
- double-stranded RNA binding
- single-stranded RNA binding
- endoribonuclease activity