RLIM
RLIM Gene Summary
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | RLIM |
| Official Name | ring finger protein, LIM domain interacting [Source:HGNC Symbol;Acc:HGNC:13429] |
| Ensembl ID | ENSG00000131263 |
| Bio databases IDs | |
| Aliases | ring finger protein, LIM domain interacting, ring zinc finger protein NY-REN-43antigen, LIM domain interacting ring finger protein, E3 ubiquitin-protein ligase RLIM |
| Synonyms | AL022832,Ha1r,LOC100910646,MRX61,NY-REN-43,ring finger protein, LIM domain interacting,Rlim1,Rliml1,RNF12,TOKAS |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the RLIM gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- IRS4
- RPL11
- UBC
- NFE2L1
- INCENP
- FBXW11
- HBD
- HSPA8
- PPP1CC
- HDAC3
disease
- X-linked mental retardation type 61
- organismal death
- Wilms tumor
- Wilms tumorigenesis
- liver cancer
- epithelial cancer
- hereditary disorder
- hepatocellular carcinoma
- metastasis
- neoplasia
regulated by
- TP53
- beta-estradiol
- YY1
- trichostatin A
- SSBP2
- USP26
- SNCA
- black raspberry extract
- phenethyl isothiocyanate
- n-nitrosomethylbenzylamine
regulates
- CDKN1A
- SERPINE1
- AKT
- LDB1
- EGFR
- CDH2
- VIM
- Usp9y
- USP26
- CCN2
role in cell
- expression in
- migration
- induction
- phosphorylation in
- differentiation
- proliferation
- formation in
- colony formation
- JG-231 sensitivity
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RLIM gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- random inactivation of X chromosome
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- cytosol
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- metal ion binding
- transcription corepressor activity