Vps36 Gene Summary [Rat]

Predicted to enable ubiquitin binding activity. Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in cytosol; late endosome; and lysosome. Predicted to be part of ESCRT II complex. Predicted to be active in late endosome membrane. Orthologous to human VPS36 (vacuolar protein sorting 36 homolog). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Vps36
Official Name
vacuolar protein sorting 36 homolog [Source:RGD Symbol;Acc:1309754]
Ensembl ID
ENSRNOG00000012654
Bio databases IDs NCBI: 290851 Ensembl: ENSRNOG00000012654
Aliases vacuolar protein sorting 36 homolog
Synonyms 1700010A24Rik, 2210415M20RIK, 2810408E15RIK, C13ORF9, CGI-145, EAP45, RGD1309754, vacuolar protein sorting 36, vacuolar protein sorting 36 homolog
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vps36 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • EAP30/Vps36 family
  • ubiquitin binding
  • protein binding
  • Pleckstrin homology-like domain

Pathways

Biological processes and signaling networks where the Vps36 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • abdominal aortic aneurysm
  • lewy body disease
regulated by
regulates
role in cell
  • macroautophagy in
  • silencing in
  • assembly

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • endosomes
  • lysosome
  • Golgi Apparatus
  • cytosol
  • endosomal membrane
  • late endosomes
  • exosomes

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Vps36 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
  • membrane fission
  • macroautophagy

Cellular Component

Where in the cell the gene product is active
  • late endosome membrane
  • nucleus
  • extracellular vesicular exosome
  • endosome
  • ESCRT II complex
  • cytosol
  • lysosome

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • ubiquitin binding
  • phosphatidylinositol-3-phosphate binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.