RNF144B Gene Summary [Human]
Enables ubiquitin-protein transferase activity. Involved in negative regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Located in mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RNF144B |
| Official Name | ring finger protein 144B [Source:HGNC Symbol;Acc:HGNC:21578] |
| Ensembl ID | ENSG00000137393 |
| Bio databases IDs | |
| Aliases | ring finger protein 144B |
| Synonyms | bA528A10.3, BC025007, E130105P19Rik, IBRDC2, LOC103694052, p53RFP, PIR2, ring finger protein 144B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF144B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IBR domain, a half RING-finger domain
- In Between Ring fingers
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- BRcat_Rcat_RBR
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary prostate cancer
- serous ovarian adenocarcinoma
- serous ovarian cancer
- metastatic prostate cancer
- osteoarthritis
- early missed abortion
- chordoma
- bone cancer
- COVID-19
- finger osteoarthritis
role in cell
- expression in
- apoptosis
- proliferation
- colony formation
- differentiation
- migration
- invasion by
- glycolysis in
- degradation in
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- mitochondrial membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF144B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- negative regulation of apoptotic process
- apoptotic process
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- ubiquitin ligase complex
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- ubiquitin conjugating enzyme binding
- protein binding