CENPU Gene Summary [Human]
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | CENPU |
| Official Name | centromere protein U [Source:HGNC Symbol;Acc:HGNC:21348] |
| Ensembl ID | ENSG00000151725 |
| Bio databases IDs | |
| Aliases | centromere protein U, polo-box-interacting protein 1 |
| Synonyms | 1700029A22RIK, CENP50, CENPU50, centromere protein U, FLJ23468, KLIP1, MLF1IP, PBIP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CENPU often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CENP-A nucleosome associated complex (NAC) subunit
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- renal cell cancer
- invasive breast cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- metastasis
- organismal death
- breast carcinoma
- Kawasaki disease
role in cell
- expression in
- proliferation
- migration
- degradation in
- upregulation in
- invasion by
- cohesion
- cohesion in
- misorientation in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CENPU gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chordate embryonic development
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome inner kinetochore
- centriolar satellite
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding