FXYD6 Gene Summary [Human]

This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]

Details

Type
Protein Coding
Official Symbol
FXYD6
Official Name
FXYD domain containing ion transport regulator 6 [Source:HGNC Symbol;Acc:HGNC:4030]
Ensembl ID
ENSG00000137726
Bio databases IDs NCBI: 53826 Ensembl: ENSG00000137726
Aliases FXYD domain containing ion transport regulator 6, phosphohippolin
Synonyms 0610030I18Rik, FXYD domain-containing ion transport regulator 6, Php
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FXYD6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ATP1G1/PLM/MAT8 family
  • protein binding
  • phenylalanine-X-tyrosine-aspartate (FXYD) family
  • ion channel

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • adenoma formation
  • keratocystic odontogenic tumor
  • keratocystic odontogenic tumors
  • aldosterone producing adrenocortical adenoma
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • glutaminergic synapse
  • cellular membrane
  • presynaptic membrane
  • postsynaptic membrane
  • perikaryon
  • dendrites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human FXYD6 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • potassium ion transport
  • sodium ion transport
  • regulation of sodium ion transmembrane transporter activity
  • regulation of ion transport

Cellular Component

Where in the cell the gene product is active
  • presynaptic membrane
  • postsynaptic membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • sodium channel regulator activity
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.