DTNB Gene Summary [Human]
This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]
Details
| Type | Processed Transcript |
| Official Symbol | DTNB |
| Official Name | dystrobrevin beta [Source:HGNC Symbol;Acc:HGNC:3058] |
| Ensembl ID | ENSG00000138101 |
| Bio databases IDs | |
| Aliases | dystrobrevin beta |
| Synonyms | dystrobrevin beta, dystrobrevin, beta, dystrobrevin β, dystrobrevin, β, β dystrobrevin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DTNB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- ZZ
- EF hand
- EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
- Uso1 / p115 like vesicle tethering protein, C terminal region
- coiled-coil domain
- zinc finger domain
- protein binding
- Cell division protein ZapB
- DNA binding
- JNK_SAPK-associated protein-1
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- plasma cell myeloma
- lung adenocarcinoma
- lung adenocarcinoma formation
- cutaneous melanoma
- cutaneous melanoma cancer
- Crohn disease
role in cell
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- soluble fraction
- postsynaptic density (PSD) fractions
- Cytoplasm
- postsynaptic region
- Nucleus
- microsome
- basolateral membrane
- synapse
- perikaryon
- axons
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DTNB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
Cellular Component
Where in the cell the gene product is active
- inhibitory synapse
- dendrite
- nucleus
- postsynaptic density
- basal plasma membrane
- cytoplasm
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding