GPAT3 Gene Summary [Human]
This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Details
| Type | Processed Transcript |
| Official Symbol | GPAT3 |
| Official Name | glycerol-3-phosphate acyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:28157] |
| Ensembl ID | ENSG00000138678 |
| Bio databases IDs | |
| Aliases | glycerol-3-phosphate acyltransferase 3, lysophosphatidic acid acyltransferase, theta |
| Synonyms | 1-AGPAT, 1-AGPAT 9, 4933407I02Rik, 4933408F15, A230097K15Rik, AGPAT 10, AGPAT8, AGPAT9, glycerol-3-phosphate acyltransferase 3, HMFN0839, LPAAT-theta, LPAAT-θ, MAG1, mGPAT3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPAT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 1-acylglycerol-3-phosphate O-acyltransferase
- glycerol-3-phosphate O-acyltransferase
- enzyme
- protein binding
- Acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- colorectal cancer
- diabetic nephropathy
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- obesity
- acute myeloid leukemia
- breast carcinoma
- hyperactive behavior
role in cell
- expression in
- lipotoxicity in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- inner nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPAT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol-3-phosphate metabolic process
- triglyceride biosynthetic process
- CDP-diacylglycerol biosynthetic process
- phosphatidic acid biosynthetic process
- regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- glycerol-3-phosphate O-acyltransferase activity