CERS5 Gene Summary [Human]
This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CERS5 |
| Official Name | ceramide synthase 5 [Source:HGNC Symbol;Acc:HGNC:23749] |
| Ensembl ID | ENSG00000139624 |
| Bio databases IDs | |
| Aliases | ceramide synthase 5 |
| Synonyms | 2310081H14RIK, ceramide synthase 5, LASS5, Trh4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CERS5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TLC domain
- sphingosine N-acyltransferase
- enzyme
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- obesity
- impaired glucose tolerance
- weight gain
- azoxymethane/dextran sodium sulfate induced colorectal cancer
role in cell
- expression in
- cell death
- permeabilization
- accumulation in
- production in
- permeabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CERS5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte development
- ceramide biosynthetic process
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sphingosine N-acyltransferase activity