P2RY12 Gene Summary [Human]
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | P2RY12 |
| Official Name | purinergic receptor P2Y12 [Source:HGNC Symbol;Acc:HGNC:18124] |
| Ensembl ID | ENSG00000169313 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2Y12 |
| Synonyms | 2900079B22Rik, 4921504D23Rik, ADPG-R, BDPLT8, HORK3, P2TAC, P2T(AC), P2Y12, P2Y(12)R, P2Y12 receptor, P2Y(AC), P2Y(ADP), P2Y(cyc), purinergic receptor P2Y12, purinergic receptor P2Y, G-protein coupled 12, SP1999 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human P2RY12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- G-protein coupled adenosine receptor
- guanyl-nucleotide exchange factor
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- cytosolic tail domain
- platelet ADP receptor
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the P2RY12 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- heart failure
- chronic kidney disease
- atrial fibrillation
- non-insulin-dependent diabetes mellitus
- renal failure
- disorder of coronary artery
- acute coronary syndrome
- unstable angina
- hypertension
role in cell
- quantity
- production in
- cellular infiltration by
- migration
- expression in
- activation in
- binding
- adhesion
- aggregation
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular compartment
- cell surface
- intracellular space
- cellular membrane
- plasma membrane extracellular face
- caveolae
- basal membrane
- cellular protrusions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human P2RY12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- cell projection organization
- response to axon injury
- hemostasis
- ion transport
- positive regulation of ion transport
- positive regulation of cell adhesion mediated by integrin
- establishment of localization in cell
- cellular response to ATP
- calcium-mediated signaling
- platelet activation
- platelet aggregation
- G-protein coupled receptor signaling pathway
- cerebral cortex radial glia guided migration
- phospholipase C-activating G-protein coupled receptor signaling pathway
- substrate-dependent cell migration, cell extension
- positive regulation of ruffle assembly
- adenosine receptor signaling pathway
- positive regulation of integrin activation by cell surface receptor linked signal transduction
- lamellipodium assembly
- regulation of chemotaxis
- positive regulation of chemotaxis
- positive regulation of protein kinase B signaling cascade
- G-protein coupled purinergic nucleotide receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cell body membrane
- membrane
- cell projection membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ADP receptor activity
- guanyl-nucleotide exchange factor activity
- G-protein coupled purinergic nucleotide receptor activity
- G-protein coupled adenosine receptor activity