MDGA2 Gene Summary [Human]
Predicted to be involved in regulation of presynapse assembly; regulation of synaptic membrane adhesion; and spinal cord motor neuron differentiation. Predicted to act upstream of or within neuron migration and pattern specification process. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in GABA-ergic synapse and glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MDGA2 |
| Official Name | MAM domain containing glycosylphosphatidylinositol anchor 2 [Source:HGNC Symbol;Acc:HGNC:19835] |
| Ensembl ID | ENSG00000139915 |
| Bio databases IDs | |
| Aliases | MAM domain containing glycosylphosphatidylinositol anchor 2 |
| Synonyms | 6720489L24RIK, 9330209L04RIK, Adp, c14 5286, MAMDC1, MAM domain containing glycosylphosphatidylinositol anchor 2, Tg(Prnp-PFN1*G118V)838Kiaei |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MDGA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- MAM domain, meprin/A5/mu
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- non-insulin-dependent diabetes mellitus
- clear cell sarcoma of the kidney
- renal cancer
- soft tissue sarcoma cancer
- neuroticism
- food allergy
- major depression
- ocular sarcoidosis
- gastric cancer
regulated by
- topotecan
- methylphenidate
- levodopa
role in cell
- expression in
- migration
- apoptosis
- differentiation
- growth
- proliferation
- stabilization in
- colony formation
- adhesion
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Extracellular Space
- cellular membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MDGA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spinal cord motor neuron differentiation
- nervous system development
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane