PELI2 Gene Summary [Human]
Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase activity. Acts upstream of or within positive regulation of MAPK cascade and positive regulation of protein phosphorylation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PELI2 |
| Official Name | pellino E3 ubiquitin protein ligase family member 2 [Source:HGNC Symbol;Acc:HGNC:8828] |
| Ensembl ID | ENSG00000139946 |
| Bio databases IDs | |
| Aliases | pellino E3 ubiquitin protein ligase family member 2 |
| Synonyms | LOC107984656, Pellino2, pellino E3 ubiquitin protein ligase family member 2, RGD1565884 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PELI2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ring like zinc finger domain
- ubiquitin protein ligase activity
- protein binding activity, bridging
- enzyme
- protein binding
- Pellino
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- schizophrenia
- chronic obstructive pulmonary disease
- lupus erythematosus
- asthma
- infection by human herpesvirus 1
role in cell
- apoptosis
- expression in
- binding in
- activation in
- phosphorylation in
- K48 polyubiquitination in
- K63 polyubiquitination in
- polyubiquitination in
- mRNA decay in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PELI2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- regulation of Toll signaling pathway
- positive regulation of protein phosphorylation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin-ubiquitin ligase activity