TAF4B Gene Summary [Human]
TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Details
| Type | Protein Coding |
| Official Symbol | TAF4B |
| Official Name | TATA-box binding protein associated factor 4b [Source:HGNC Symbol;Acc:HGNC:11538] |
| Ensembl ID | ENSG00000141384 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 4b, TATA box binding protein (TBP)-associated factor 4B |
| Synonyms | 2610524B04RIK, 4932409F03RIK, RGD1562997, SPGF13, TAF2C2, Taf4b (predicted), TAFII-105, TATA-box binding protein associated factor 4b |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAF4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- Transcription initiation factor TFIID component TAF4 family
- transcription regulator
- NHR1 homology to TAF
- spacer domain
- NF-kappaB binding
- TAF homology
- protein binding
- zDHHC ankyrin repeat binding domain
- DNA binding
Pathways
Biological processes and signaling networks where the TAF4B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- alcoholic cirrhosis
- Bell palsy
- oligozoospermia
- chronic obstructive asthma
- spermatogenic failure 13
- premature ovarian failure
- asthenozoospermia
role in cell
- cell viability
- apoptosis
- proliferation
- survival
- maturation
- cell-cell contact
- quantity
- morphology
- abnormal morphology
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- Cytoplasm
- nucleoplasm
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAF4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- oogenesis
- positive regulation of transcription initiation from RNA polymerase II promoter
- spermatogenesis
- transcription initiation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- cytoplasm
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- DNA binding
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity