SLC16A3 Gene Summary [Human]
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLC16A3 |
| Official Name | solute carrier family 16 member 3 [Source:HGNC Symbol;Acc:HGNC:10924] |
| Ensembl ID | ENSG00000141526 |
| Bio databases IDs | |
| Aliases | solute carrier family 16 member 3 |
| Synonyms | MCT-3, MCT-4, solute carrier family 16 member 3, solute carrier family 16 (monocarboxylic acid transporters), member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC16A3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- lactate:hydrogen porter
- Major Facilitator Superfamily
- protein binding
- monocarboxylic acid transporter
- monocarboxylate transporter 1
- zDHHC ankyrin repeat binding domain
- transporter
- lactate transporter
Pathways
Biological processes and signaling networks where the SLC16A3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- proteinuria
- lung adenocarcinoma
- lung adenocarcinoma formation
- metastatic colorectal cancer
- cleft palate
- cleft lip
- organismal death
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- expression in
- glycolysis in
- action potential
- proliferation
- abnormal morphology
- pruning
- pH
- accumulation in
- acidification in
- acidification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- cellular membrane
- Mitochondria
- apical membrane
- synaptic membrane
- basolateral membrane
- lateral plasma membrane
- nuclear envelope
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC16A3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyruvate catabolic process
- monocarboxylic acid transport
- lactate transmembrane transport
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- lateral plasma membrane
- membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- lactate:hydrogen symporter activity
- pyruvate transmembrane transporter activity
- monocarboxylic acid transmembrane transporter activity