POGZ Gene Summary [Human]
The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | POGZ |
| Official Name | pogo transposable element derived with ZNF domain [Source:HGNC Symbol;Acc:HGNC:18801] |
| Ensembl ID | ENSG00000143442 |
| Bio databases IDs | |
| Aliases | pogo transposable element derived with ZNF domain, zinc finger protein 280E, putative protein product of Nbla00003 |
| Synonyms | 9530006B08Rik, KIAA0461, LOC102546890, MRD37, pogo transposable element derived with ZNF domain, pogo transposable element with ZNF domain, WHSUS, ZNF280E, ZNF635, ZNF635m |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POGZ often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tc5 transposase DNA-binding domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- organismal death
- autosomal dominant mental retardation type 37
- pervasive developmental disorder
- hypoplasia
- hereditary disorder
- anemia
- mental retardation
- neurodevelopmental disorder
- obesity
role in cell
- activation in
- assembly
- binding in
- dissociation in
- dissociation
- mitosis
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- basal bodies
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POGZ gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic sister chromatid cohesion
- double-strand break repair via homologous recombination
- kinetochore assembly
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding