TINAGL1 Gene Summary [Human]
The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | TINAGL1 |
| Official Name | tubulointerstitial nephritis antigen like 1 [Source:HGNC Symbol;Acc:HGNC:19168] |
| Ensembl ID | ENSG00000142910 |
| Bio databases IDs | |
| Aliases | tubulointerstitial nephritis antigen like 1, androgen regulated gene 1 |
| Synonyms | 1110021J17Rik, ARG1, AZ-1, Gis5, LCN7, LIECG3, Lipocalin 7, OLRG-2, pp6614, TARP, TINAGL, TINAGRP, tubulointerstitial nephritis antigen-like 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TINAGL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- laminin binding
- Peptidase_C1
- protein binding
- Somatomedin B domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular vesicles
- Cytoplasm
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TINAGL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- endosomal transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- extracellular region
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- cysteine-type peptidase activity
- extracellular matrix structural constituent
- laminin binding