ITGA10 Gene Summary [Human]
Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | ITGA10 |
| Official Name | integrin subunit alpha 10 [Source:HGNC Symbol;Acc:HGNC:6135] |
| Ensembl ID | ENSG00000143127 |
| Bio databases IDs | |
| Aliases | integrin subunit alpha 10 |
| Synonyms | A630048L14, INTEGRIN alpha 10, integrin, alpha 10, integrin subunit alpha 10, integrin subunit α 10, INTEGRIN α 10, integrin, α 10, LOC101060422, PRO827 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ITGA10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin alpha (beta-propellor repeats)
- Integrin alpha
- von Willebrand factor (vWF) type A domain
- cell adhesion molecule binding
- vWFA
- collagen binding
- von Willebrand factor type A domain
- inserted domain
- FG-GAP repeat
Pathways
Biological processes and signaling networks where the ITGA10 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Cdc42 Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HGF Signaling
- Integrin Signaling
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- PAK Signaling
- Paxillin Signaling
- PI3K/AKT Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- intellectual disability and developmental delay
- single suture craniosynostosis
regulates
- Collagen type ix
role in cell
- binding
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ITGA10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- integrin-mediated signaling pathway
- cell adhesion mediated by integrin
Cellular Component
Where in the cell the gene product is active
- alpha10-beta1 integrin complex
- external side of plasma membrane
- integrin complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- collagen binding
- metal ion binding
- integrin binding