LGALS12 Gene Summary [Human]
This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | LGALS12 |
| Official Name | galectin 12 [Source:HGNC Symbol;Acc:HGNC:15788] |
| Ensembl ID | ENSG00000133317 |
| Bio databases IDs | |
| Aliases | galectin 12 |
| Synonyms | GAL12, galectin 12, GRIP1, lectin, galactose binding, soluble 12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LGALS12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GLECT
- lactose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- obesity
- impaired glucose tolerance
- primary prostate cancer
- Ullrich congenital muscular dystrophy
role in cell
- growth
- apoptosis
- signaling in
- differentiation
- cell cycle progression
- size
- mitochondrial respiration in
- lipolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- mitochondrial fraction
- Nucleus
- Mitochondria
- lipid droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LGALS12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- lactose binding