FGD2 Gene Summary [Human]
The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system. [provided by RefSeq, Oct 2016]
Details
| Type | Retained Intron |
| Official Symbol | FGD2 |
| Official Name | FYVE, RhoGEF and PH domain containing 2 [Source:HGNC Symbol;Acc:HGNC:3664] |
| Ensembl ID | ENSG00000146192 |
| Bio databases IDs | |
| Aliases | FYVE, RhoGEF and PH domain containing 2 |
| Synonyms | FYVE, RhoGEF and PH domain containing 2, TCD2, tcs-2, ZFYVE4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FGD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- RhoGEF
- Protein present in Fab1, YOTB, Vac1, and EEA1
- guanyl-nucleotide exchange factor
- PH domain
- enzyme binding
- PHD finger superfamily
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Nucleus
- Golgi Apparatus
- cytosol
- early endosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FGD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cytoskeleton organization
- regulation of small GTPase mediated signal transduction
- regulation of GTPase activity
- actin cytoskeleton organization
- filopodium assembly
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- nucleus
- cytoskeleton
- cytoplasm
- ruffle
- ruffle membrane
- cytosol
- Golgi apparatus
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding