PPP1R1B Gene Summary [Human]
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | PPP1R1B |
| Official Name | protein phosphatase 1 regulatory inhibitor subunit 1B [Source:HGNC Symbol;Acc:HGNC:9287] |
| Ensembl ID | ENSG00000131771 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 regulatory inhibitor subunit 1B, dopamine and cAMP regulated phosphoprotein |
| Synonyms | DARPP, DARPP-32, Dopamine and camp regulated neuronal phosphoprotein, protein phosphatase 1 regulatory inhibitor subunit 1B, protein phosphatase 1, regulatory (inhibitor) subunit 1B, protein phosphatase 1, regulatory inhibitor subunit 1B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1R1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- type 1 serine/threonine specific protein phosphatase inhibitor
- phosphoprotein phosphatase
- protein kinase inhibitor activity
- G-protein-coupled receptor binding
- protein phosphatase regulator
- protein binding
- phosphorylation site
- protein phosphatase inhibitor activity
- cAMP-dependent protein kinase inhibitor activity
- RKKIQF motif
- phosphatase
- Pka phosphorylation site
- Protein phosphatase inhibitor 1/DARPP-32
Pathways
Biological processes and signaling networks where the PPP1R1B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- esophageal cancer
- schizophrenia
- Huntington disease
- diabetic nephropathy
- gastric cancer
- colorectal cancer
- age-related macular degeneration
- survival
- dyskinesia
role in cell
- growth
- proliferation
- upregulation in
- expression in
- activation in
- binding in
- phosphorylation in
- cell viability
- apoptosis
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- Nucleus
- cytosol
- dendritic spine neck
- dendritic spine head
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP1R1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of phosphoprotein phosphatase activity
- locomotory behavior
- behavioral response to cocaine
- response to amphetamine
- transcription, DNA-dependent
- signal transduction
- cellular response to cocaine
- visual learning
- response to morphine
- intracellular signal transduction
- negative regulation of female receptivity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- protein binding
- protein kinase inhibitor activity
- cAMP-dependent protein kinase inhibitor activity
- protein phosphatase regulator activity