SCGB1A1 Gene Summary [Human]
This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | SCGB1A1 |
| Official Name | secretoglobin family 1A member 1 [Source:HGNC Symbol;Acc:HGNC:12523] |
| Ensembl ID | ENSG00000149021 |
| Bio databases IDs | |
| Aliases | secretoglobin family 1A member 1, Uteroglobin (Clara cell specific 10-kD protein), club cell protein 16, club secretory protein 16 |
| Synonyms | CC10, CC16, CCPBP, CCSP, PCBB, PCB-BP, secretoglobin family 1A member 1, secretoglobin, family 1A, member 1, Ueteroglobin csp, UG, UGB, UP-1, URINE protein 1, uteroglobin, Utg |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCGB1A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- cytokine
- Secretoglobin
Pathways
Biological processes and signaling networks where the SCGB1A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- proteinuria
- fibrosis
- epithelial neoplasia
- lung metastasis
- hyperplasia
- chronic obstructive pulmonary disease
- cortical renal glomerulopathies
- cachexia
- adenoma formation
role in cell
- phosphorylation in
- proliferation
- number
- binding
- expression in
- activation in
- apoptosis
- invasion
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- intracellular space
- endosomes
- lysosome
- nuclear envelope
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCGB1A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- signal transduction
- response to silicon dioxide
- response to ozone
- female pregnancy
- regulation of mRNA stability
- response to xenobiotic stimulus
- embryo implantation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of interleukin-4 production
- negative regulation of interleukin-5 production
- negative regulation of T cell proliferation
- response to glucocorticoid stimulus
- T cell proliferation
- negative regulation of interleukin-13 production
- regulation of inflammatory response
- response to lipopolysaccharide
- response to fibroblast growth factor stimulus
- negative regulation of interferon-gamma production
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- secretory granule
Molecular Function
What the gene product does at the molecular level
- protein binding
- polychlorinated biphenyl binding
- phospholipase A2 inhibitor activity