Scgb1a1 Gene Summary [Rat]
Enables polychlorinated biphenyl binding activity. Involved in several processes, including response to lipopolysaccharide; response to ozone; and response to silicon dioxide. Located in extracellular space; nuclear envelope; and secretory granule. Biomarker of acute kidney failure; asthma; otitis media; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; and glomerulonephritis. Orthologous to human SCGB1A1 (secretoglobin family 1A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scgb1a1 |
| Official Name | secretoglobin family 1A member 1 [Source:RGD Symbol;Acc:3934] |
| Ensembl ID | ENSRNOG00000020196 |
| Bio databases IDs | |
| Aliases | secretoglobin family 1A member 1 |
| Synonyms | CC10, CC16, CCPBP, CCSP, PCBB, PCB-BP, secretoglobin family 1A member 1, secretoglobin, family 1A, member 1, Ueteroglobin csp, UG, UGB, UP-1, URINE protein 1, uteroglobin, Utg |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scgb1a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- cytokine
- Secretoglobin
Pathways
Biological processes and signaling networks where the Scgb1a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- proteinuria
- fibrosis
- epithelial neoplasia
- lung metastasis
- hyperplasia
- chronic obstructive pulmonary disease
- cortical renal glomerulopathies
- cachexia
- adenoma formation
role in cell
- phosphorylation in
- proliferation
- number
- binding
- expression in
- activation in
- apoptosis
- invasion
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- intracellular space
- endosomes
- lysosome
- nuclear envelope
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scgb1a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- signal transduction
- response to silicon dioxide
- response to ozone
- female pregnancy
- regulation of mRNA stability
- response to xenobiotic stimulus
- embryo implantation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of interleukin-4 production
- negative regulation of interleukin-5 production
- negative regulation of T cell proliferation
- response to glucocorticoid stimulus
- T cell proliferation
- negative regulation of interleukin-13 production
- regulation of inflammatory response
- response to lipopolysaccharide
- response to fibroblast growth factor stimulus
- negative regulation of interferon-gamma production
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- secretory granule
Molecular Function
What the gene product does at the molecular level
- protein binding
- polychlorinated biphenyl binding
- phospholipase A2 inhibitor activity