PLCH2 Gene Summary [Human]
PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009]
Details
| Type | Protein Coding |
| Official Symbol | PLCH2 |
| Official Name | phospholipase C eta 2 [Source:HGNC Symbol;Acc:HGNC:29037] |
| Ensembl ID | ENSG00000149527 |
| Bio databases IDs | |
| Aliases | phospholipase C eta 2, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 |
| Synonyms | A930027K05Rik, KIAA0450, phospholipase C eta 2, phospholipase C, eta 2, PLC-eta2, PLC-L4, RGD1304675 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLCH2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphatidylinositol-specific phospholipase C, Y domain
- EF-hand, calcium binding motif
- RCSD region
- EF-hand domain pair
- KLF1_2_4_N
- EFh
- enzyme
- phospholipase C
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- Pleckstrin homology-like domain
- EFh_PI-PLC
- Phosphatidylinositol-specific phospholipase C, X domain
- phosphoinositide phospholipase C
- EF-hand domain
- Phospholipase C, catalytic domain (part: domain X)
- Phosphoinositide-specific phospholipase C, efhand-like
- EF hand
- Phospholipase C, catalytic domain (part: domain Y)
- Protein kinase C conserved region 2 (CalB)
- Pleckstrin homology domain
- C2 domain
Pathways
Biological processes and signaling networks where the PLCH2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLCH2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylinositol-mediated signaling
- lipid catabolic process
- phosphatidylinositol metabolic process
- release of sequestered calcium ion into cytosol
- phospholipase C-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- calcium ion binding