Plch2 Gene Summary [Mouse]
Enables phospholipase C activity. Acts upstream of or within phosphatidylinositol metabolic process. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; integumental system; lower urinary tract; and sensory organ. Orthologous to human PLCH2 (phospholipase C eta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plch2 |
| Official Name | phospholipase C, eta 2 [Source:MGI Symbol;Acc:MGI:2443078] |
| Ensembl ID | ENSMUSG00000029055 |
| Bio databases IDs | |
| Aliases | phospholipase C, eta 2 |
| Synonyms | A930027K05Rik, KIAA0450, phospholipase C eta 2, phospholipase C, eta 2, PLC-eta2, PLC-L4, RGD1304675 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plch2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphatidylinositol-specific phospholipase C, Y domain
- EF-hand, calcium binding motif
- RCSD region
- EF-hand domain pair
- KLF1_2_4_N
- EFh
- enzyme
- phospholipase C
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- Pleckstrin homology-like domain
- EFh_PI-PLC
- Phosphatidylinositol-specific phospholipase C, X domain
- phosphoinositide phospholipase C
- EF-hand domain
- Phospholipase C, catalytic domain (part: domain X)
- Phosphoinositide-specific phospholipase C, efhand-like
- EF hand
- Phospholipase C, catalytic domain (part: domain Y)
- Protein kinase C conserved region 2 (CalB)
- Pleckstrin homology domain
- C2 domain
Pathways
Biological processes and signaling networks where the Plch2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Aldosterone Signaling in Epithelial Cells
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Axonal Guidance Signaling
- Cardiac Hypertrophy Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- CREB Signaling in Neurons
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- Estrogen Receptor Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Glioblastoma Multiforme Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Leptin Signaling in Obesity
- Neuropathic Pain Signaling in Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- Protein Kinase A Signaling
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plch2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylinositol-mediated signaling
- lipid catabolic process
- phosphatidylinositol metabolic process
- release of sequestered calcium ion into cytosol
- phospholipase C-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- calcium ion binding