DLG2 Gene Summary [Human]

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]

Details

Type
Protein Coding
Official Symbol
DLG2
Official Name
discs large MAGUK scaffold protein 2 [Source:HGNC Symbol;Acc:HGNC:2901]
Ensembl ID
ENSG00000150672
Bio databases IDs NCBI: 1740 Ensembl: ENSG00000150672
Aliases discs large MAGUK scaffold protein 2, protein phosphatase 1, regulatory subunit 58
Synonyms A330103J02Rik, B230218P12RIK, B330007M19Rik, Chapsyn-110, discs large MAGUK scaffold protein 2, Dlgh2, Gm1197, Gm21505, LOC108349816, PPP1R58, PSD-93
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DLG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Domain present in PSD-95, Dlg, and ZO-1/2
  • L27_1
  • protein phosphatase binding
  • canonical PDZ domain
  • protein binding
  • PDZ domain
  • PDZ-domain binding
  • Src Homology 3 domain superfamily
  • L27 domain
  • kinase
  • guanylate kinase
  • Veli/LIN-7 binding domain
  • kinase binding
  • Polyubiquitination (PEST) N-terminal domain of MAGUK
  • binding protein
  • NK
  • guanylate kinase-like domain
  • structural molecule
  • cpPDZ_Deg_HtrA-like
  • PDZ-associated domain of NMDA receptors

Pathways

Biological processes and signaling networks where the DLG2 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • chronic obstructive pulmonary disease
  • alcoholism
  • osteoarthritis
  • Parkinson disease
  • cardiovascular disorder
  • schizophrenia
  • insomnia
  • tinnitus
  • non-insulin-dependent diabetes mellitus
  • periodontitis
regulated by
regulates
role in cell
  • migration
  • formation
  • formation in
  • morphology
  • response by
  • sprouting angiogenesis by
  • disassembly in
  • replication in
  • clustering in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • postsynaptic density (PSD) fractions
  • synaptic vesicle membrane
  • glutaminergic synapse
  • cell junction
  • axon component
  • Cytoplasm
  • cellular membrane
  • microtubules
  • cytosol
  • postsynaptic membrane
  • synaptic membrane
  • dendritic spines
  • growth cone
  • dendritic trees
  • juxtaparanodes
  • synaptosomes
  • synapse
  • smooth endoplasmatic reticulum
  • membrane rafts
  • perikaryon
  • dendrites
  • postsynaptic density
  • synaptosomal fractions

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human DLG2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • embryo development
  • establishment or maintenance of epithelial cell apical/basal polarity
  • GDP metabolic process
  • synaptic transmission
  • GMP metabolic process
  • receptor clustering
  • receptor localization to synapse
  • cellular response to potassium ion

Cellular Component

Where in the cell the gene product is active
  • postsynaptic density
  • adherens junction
  • voltage-gated potassium channel complex
  • membrane
  • cytosol
  • neuromuscular junction
  • juxtaparanode region of axon
  • perikaryon
  • basolateral plasma membrane
  • neuron projection
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein kinase binding
  • ionotropic glutamate receptor binding
  • protein binding
  • guanylate kinase activity
  • kinase binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.