PARP8 Gene Summary [Human]
Enables protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | PARP8 |
| Official Name | poly(ADP-ribose) polymerase family member 8 [Source:HGNC Symbol;Acc:HGNC:26124] |
| Ensembl ID | ENSG00000151883 |
| Bio databases IDs | |
| Aliases | poly(ADP-ribose) polymerase family member 8 |
| Synonyms | 2810430O08Rik, ARTD16, D13Ertd275e, FLJ21308, pART16, poly (ADP-ribose) polymerase family, member 8, poly(ADP-ribose) polymerase family member 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PARP8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pentosyltransferase
- enzyme
- ADP_ribosyl
Pathways
Biological processes and signaling networks where the PARP8 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- neuroblastoma
- neuroblastoma formation
- non-insulin-dependent diabetes mellitus
- pathologic myopia
- coronary artery disease
- early missed abortion
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PARP8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endoplasmic reticulum unfolded protein response
- protein auto-ADP-ribosylation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum tubular network
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- protein serine/threonine kinase activator activity
- kinase binding
- NAD+ ADP-ribosyltransferase activity