TIAL1 Gene Summary [Human]
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TIAL1 |
| Official Name | TIA1 cytotoxic granule associated RNA binding protein like 1 [Source:HGNC Symbol;Acc:HGNC:11804] |
| Ensembl ID | ENSG00000151923 |
| Bio databases IDs | |
| Aliases | TIA1 cytotoxic granule associated RNA binding protein like 1, TIA1 related |
| Synonyms | 5330433G13Rik, mTIAR, NUCLEOLYSIN, TCBP, TIA1 cytotoxic granule associated RNA binding protein like 1, TIAR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TIAL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RNA recognition motif (RRM) superfamily
- transcription regulator
- mRNA 3' UTR binding
- RNA recognition motif
- protein binding activity, bridging
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- growth failure
- infection by Hepatitis C virus genotype 2
role in cell
- cell death
- upregulation in
- proliferation
- formation
- formation in
- number
- S phase
- size
- generation in
- metabolism in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- lysosome
- cytosol
- nucleoplasm
- cytotoxic granule
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TIAL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- positive regulation of hippo signaling cascade
- positive regulation of gene silencing by miRNA
- negative regulation of cell proliferation
- positive regulation of stem cell proliferation
- stem cell proliferation
- apoptotic process
- stem cell division
- defense response
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytolytic granule
- cytoplasmic stress granule
- cytoplasm
- cytosol
- nucleoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- mRNA 3'-UTR AU-rich region binding
- mRNA 3'-UTR binding