THY1 Gene Summary [Human]
This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | THY1 |
| Official Name | Thy-1 cell surface antigen [Source:HGNC Symbol;Acc:HGNC:11801] |
| Ensembl ID | ENSG00000154096 |
| Bio databases IDs | |
| Aliases | Thy-1 cell surface antigen |
| Synonyms | CD7, CD90, CDw90, LOC94105, T25, Thy-1 cell surface antigen, Thymus cell antigen 1, theta, Thymus cell antigen 1, θ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THY1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- protein kinase binding
- Immunoglobulin V-Type
- immunoglobulin domain
- RGD motif
- enzyme binding
- GTPase activator
- protein binding
- phosphatidylinositol binding
- RGD-like domain
- binding protein
- integrin binding
- Immunoglobulin like
- immunoglobulin-like protein domain
Pathways
Biological processes and signaling networks where the THY1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- prostate cancer
- fibrosis
- dermatomyositis
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- liver cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- migration
- expression in
- tubulation
- activation in
- formation in
- production in
- activation
- differentiation
- proliferation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- myelin enriched fraction
- synaptic plasma membrane fractions
- raft fractions
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cell surface
- Extracellular Space
- postsynaptic region
- cellular membrane
- Nucleus
- vesicles
- Endoplasmic Reticulum
- cytosol
- plasma membrane extracellular face
- apical membrane
- synaptic vesicles
- axonal membrane
- growth cone
- membrane rafts
- perikaryon
- axons
- dendrites
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THY1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- cell-cell signaling
- receptor clustering
- positive regulation of release of sequestered calcium ion into cytosol
- retinal cone cell development
- positive regulation of cellular extravasation
- negative regulation of protein kinase activity
- positive regulation of GTPase activity
- integrin-mediated signaling pathway
- negative regulation of axonogenesis
- positive regulation of T cell activation
- positive regulation of focal adhesion assembly
- negative regulation of T cell receptor signaling pathway
- regulation of cell-matrix adhesion
- angiogenesis
- negative regulation of neuron projection regeneration
- regulation of Rho-dependent protein serine/threonine kinase activity
- heterotypic cell-cell adhesion
- focal adhesion assembly
- negative regulation of cell migration
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite membrane
- external side of plasma membrane
- endoplasmic reticulum
- neuronal cell body membrane
- extracellular region
- plasma membrane
- cell surface
- growth cone
- dendrite
- extracellular vesicular exosome
- focal adhesion
- membrane raft
- axolemma
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- integrin binding
- GPI anchor binding