JAM2 Gene Summary [Human]
This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | JAM2 |
| Official Name | junctional adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:14686] |
| Ensembl ID | ENSG00000154721 |
| Bio databases IDs | |
| Aliases | junctional adhesion molecule 2 |
| Synonyms | 1110002N23Rik, 2410030G21Rik, 2410167M24Rik, C21orf43, CD322, IBGC8, JAM-B, Jcam2, junction adhesion molecule 2, junctional adhesion molecule 2, PRO245, VE-JAM |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human JAM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Ig-like C2 domain
- integrin binding
- Immunoglobulin like
- Immunoglobulin I-set domain
- cytosolic tail domain
- protein binding
- Ig-like V domain
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the JAM2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- autosomal recessive idiopathic basal ganglia calcification type 8
- Duchenne muscular dystrophy
role in cell
- phosphorylation in
- frequency
- activation in
- development
- function
- formation
- number
- abnormal morphology
- disorganization
- tubulogenesis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cell borders
- somatodendritic region
- cellular membrane
- intercellular junctions
- cell-cell contacts
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human JAM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lymphocyte aggregation
- spermatid development
- cellular extravasation
- myoblast fusion
- leukocyte tethering or rolling
- positive regulation of lymphocyte migration
- leukocyte cell-cell adhesion
- negative regulation of myelination
- maintenance of blood-brain barrier
- hematopoietic stem cell migration to bone marrow
Cellular Component
Where in the cell the gene product is active
- cell-cell contact zone
- occluding junction
- tight junction
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- integrin binding