PLCL2 Gene Summary [Human]
Enables GABA receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within several processes, including B cell activation; gamma-aminobutyric acid signaling pathway; and negative regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | PLCL2 |
| Official Name | phospholipase C like 2 [Source:HGNC Symbol;Acc:HGNC:9064] |
| Ensembl ID | ENSG00000154822 |
| Bio databases IDs | |
| Aliases | phospholipase C like 2 |
| Synonyms | LOC102557397, LOC680128, mKIAA1092, PHOSPHOLIPASE C-LIKE 2, PLCE2, PRIP-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLCL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphatidylinositol-specific phospholipase C, Y domain
- enzyme
- protein binding
- receptor binding
- Pleckstrin homology-like domain
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- EFh_PI-PLC
- Phosphatidylinositol-specific phospholipase C, X domain
- Phospholipase C, catalytic domain (part: domain X)
- Phosphoinositide-specific phospholipase C, efhand-like
- Phospholipase C, catalytic domain (part: domain Y)
- PH domain
- Protein kinase C conserved region 2 (CalB)
- Pleckstrin homology domain
- C2 domain
Pathways
Biological processes and signaling networks where the PLCL2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric ulcer
- schizophrenia
- anxiety disorder
- obesity
- asthma
- depressive disorder
- myocardial infarction
- neuroticism
- substance-related disorder
- opioid-related disorder
role in cell
- expression in
- phosphorylation in
- proliferation
- differentiation
- quantity
- number
- development
- lipolysis in
- contraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLCL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B-1a B cell differentiation
- lipid metabolic process
- negative regulation of B cell receptor signaling pathway
- regulation of synaptic transmission, GABAergic
- gamma-aminobutyric acid signaling pathway
- intracellular signal transduction
- B cell proliferation involved in immune response
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- GABA receptor binding
- inositol 1,4,5 trisphosphate binding