USP16 Gene Summary [Human]
This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | USP16 |
| Official Name | ubiquitin specific peptidase 16 [Source:HGNC Symbol;Acc:HGNC:12614] |
| Ensembl ID | ENSG00000156256 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 16 |
| Synonyms | 1200004E02Rik, 2810483I07Rik, 6330514E22RIK, ubiquitin specific peptidase 16, UBP-M |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription co-activator
- peptidase
- ubiquitin binding
- Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
- coiled-coil domain
- enzyme
- protein binding
- ubiquitin thiolesterase
- cysteine endopeptidase
- Zn-finger in ubiquitin-hydrolases and other protein
- zinc ion binding
- ubiquitin-specific protease
- ribosomal small subunit binding
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the USP16 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- tumorigenesis
role in cell
- expression in
- cell viability
- apoptosis
- proliferation
- phosphorylation in
- formation
- cell division
- degradation in
- misalignment
- misalignment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- monoubiquitinated protein deubiquitination
- response to DNA damage stimulus
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of translational elongation
- positive regulation of ribosome biogenesis
- regulation of transcription from RNA polymerase II promoter
- cell division
- chromatin remodeling
- protein homotetramerization
- positive regulation of transcription, DNA-dependent
- proteolysis
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- zinc ion binding
- ubiquitin binding
- transcription coactivator activity
- histone binding
- ribosomal small subunit binding
- cysteine-type endopeptidase activity