PRG3 Gene Summary [Human]
An extracellular matrix structural constituent conferring compression resistance. Involved in several processes, including granulocyte activation; histamine biosynthetic process; and regulation of gene expression. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PRG3 |
| Official Name | proteoglycan 3, pro eosinophil major basic protein 2 [Source:HGNC Symbol;Acc:HGNC:9363] |
| Ensembl ID | ENSG00000156575 |
| Bio databases IDs | |
| Aliases | proteoglycan 3, pro eosinophil major basic protein 2 |
| Synonyms | MBP2, MBPH, proteoglycan 3, proteoglycan 3, pro eosinophil major basic protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRG3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- organelle lumens
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRG3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neutrophil activation
- positive regulation of interleukin-8 production
- leukotriene biosynthetic process
- immune response
- basophil activation
- superoxide anion generation
- negative regulation of translation
- histamine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- specific granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- extracellular matrix structural constituent conferring compression resistance
- carbohydrate binding