Eif5b Gene Summary [Mouse]
Predicted to enable several functions, including GTP binding activity; GTPase activity; and translation initiation factor activity. Predicted to be involved in regulation of translational initiation; ribosome assembly; and translational initiation. Is active in synapse. Orthologous to human EIF5B (eukaryotic translation initiation factor 5B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif5b |
| Official Name | eukaryotic translation initiation factor 5B [Source:MGI Symbol;Acc:MGI:2441772] |
| Ensembl ID | ENSMUSG00000026083 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 5B |
| Synonyms | A030003E17Rik, BC018347, eukaryotic translation initiation factor 5B, IF2, Initiation Factor M2, LOC308306 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- translation initiation factor IF-2
- Elongation factor Tu domain 4
- translation initiation factor aIF-2/yIF-2
- GTPase
- protein binding
- Elongation factor Tu domain 2
- translation regulator
- GTP binding
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- PRK04004
- small GTP-binding protein domain
- translation initiation factor
- Elongation factor Tu GTP binding domain
- Ras of Complex, Roc, domain of DAPkinase
- Translation-initiation factor 2
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Eif5b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- epithelial cancer
- liver cancer
- androgenic alopecia
role in cell
- phosphorylation in
- proliferation
- expression in
- activation in
- sphere formation
- invasion by
- morphology
- assembly
- necroptosis
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif5b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosome assembly
- regulation of translational initiation
- translational initiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- synapse
Molecular Function
What the gene product does at the molecular level
- GTP binding
- translation initiation factor activity
- RNA binding
- protein binding
- metal ion binding
- GTPase activity
- tRNA binding