PIP Gene Summary [Human]
Enables IgG binding activity; aspartic-type endopeptidase activity; and identical protein binding activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of bitter taste; negative regulation of T cell apoptotic process; and proteolysis. Located in extracellular space and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PIP |
| Official Name | prolactin induced protein [Source:HGNC Symbol;Acc:HGNC:8993] |
| Ensembl ID | ENSG00000159763 |
| Bio databases IDs | |
| Aliases | prolactin induced protein, prolactin-inducible protein, gross cystic disease fluid protein 15, secretory actin-binding protein, apocrine |
| Synonyms | BRST-2, EP-GP, GCDFP-15, GPIP4, prolactin induced protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IgG binding
- DNA binding domain
- peptidase
- synergy domain
- aspartic endopeptidase
- protein binding
- identical protein binding
- Seminal vesicle autoantigen (SVA)
Pathways
Biological processes and signaling networks where the PIP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- cancer
- Down syndrome
- breast cancer
- dermatomyositis
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- Nucleus
- Endoplasmic Reticulum
- apical membrane
- perinuclear vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T cell apoptotic process
- positive regulation of gene expression
- proteolysis
- detection of chemical stimulus involved in sensory perception of bitter taste
- regulation of immune system process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- aspartic-type endopeptidase activity
- protein binding
- actin binding
- IgG binding