Fgf15 Gene Summary [Mouse]
Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within several processes, including negative regulation of bile acid biosynthetic process; neural crest cell migration; and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including brain; branchial arch endoderm; embryo ectoderm; mesonephros; and sensory organ. Orthologous to human FGF19 (fibroblast growth factor 19). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Fgf15 |
| Official Name | fibroblast growth factor 15 [Source:MGI Symbol;Acc:MGI:1096383] |
| Ensembl ID | ENSMUSG00000031073 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 15 |
| Synonyms | Fgf15, Fgf8a, fibroblast growth factor 15, fibroblast growth factor 19 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- protein binding
- fibroblast growth factor receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf15 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- neoplasia
- dysplasia
- metastasis
- epithelial cancer
- obesity
- weight gain
- diabetes mellitus
- hepatocellular carcinoma
- liver cancer
role in cell
- production in
- apoptosis
- cell viability
- number
- expression in
- migration
- proliferation
- invasion
- growth
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of bile acid biosynthetic process
- positive regulation of cell proliferation
- nervous system development
- positive regulation of glucose import
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- organ morphogenesis
- negative regulation of gene expression
- positive regulation of JNK cascade
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- cell differentiation
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- fibroblast growth factor receptor binding