CDK12 Gene Summary [Human]
Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CDK12 |
| Official Name | cyclin dependent kinase 12 [Source:HGNC Symbol;Acc:HGNC:24224] |
| Ensembl ID | ENSG00000167258 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase 12, CDC2 related protein kinase 7 |
| Synonyms | 1810022J16RIK, CRK7, CRKR, CRKRS, cyclin-dependent kinase 12, D11Ertd752e, Hgn, LOC100502717, LOC257650, Pksc |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDK12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- [RNA-polymerase]-subunit kinase
- protein kinase
- protein kinase binding
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- cyclin binding
Pathways
Biological processes and signaling networks where the CDK12 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- epithelial neoplasia
- thoracic cancer
- breast adenocarcinoma
- breast cancer
- lung adenocarcinoma formation
- non-squamous non-small cell lung cancer
- non-small cell lung cancer
role in cell
- proliferation
- cell viability
- expression in
- apoptosis
- molecular cleavage in
- survival
- phosphorylation in
- damage in
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDK12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- regulation of MAP kinase activity
- RNA splicing
- negative regulation of stem cell differentiation
- transcription from RNA polymerase II promoter
- protein autophosphorylation
- regulation of cell cycle
- mRNA processing
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- nuclear cyclin-dependent protein kinase holoenzyme complex
- positive transcription elongation factor complex b
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- protein binding
- RNA polymerase II carboxy-terminal domain kinase activity
- cyclin binding
- protein kinase activity
- cyclin-dependent protein kinase activity