PAQR3 Gene Summary [Human]
This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PAQR3 |
| Official Name | progestin and adipoQ receptor family member 3 [Source:HGNC Symbol;Acc:HGNC:30130] |
| Ensembl ID | ENSG00000163291 |
| Bio databases IDs | |
| Aliases | progestin and adipoQ receptor family member 3 |
| Synonyms | 6330415A20Rik, AY424292, LOC120096571, progestin and adipoQ receptor family member 3, progestin and adipoQ receptor family member III, RKTG |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAQR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Haemolysin-III related
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- epithelial cancer
- epithelial neoplasia
- cancer
- papillomatosis
- benign neoplasia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- hepatic steatosis
role in cell
- production in
- proliferation
- binding in
- signaling in
- differentiation
- development
- migration
- sprouting
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAQR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAP kinase activity
- negative regulation of neuron projection development
- protein localization in Golgi apparatus
- negative regulation of protein phosphorylation
- negative regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity