Paqr3 Gene Summary [Mouse]
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in negative regulation of peroxisome proliferator activated receptor signaling pathway and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within negative regulation of MAP kinase activity. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in cerebral cortex intermediate zone and cortical plate. Orthologous to human PAQR3 (progestin and adipoQ receptor family member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Paqr3 |
| Official Name | progestin and adipoQ receptor family member III [Source:MGI Symbol;Acc:MGI:2679683] |
| Ensembl ID | ENSMUSG00000055725 |
| Bio databases IDs | |
| Aliases | progestin and adipoQ receptor family member III |
| Synonyms | 6330415A20Rik, AY424292, LOC120096571, progestin and adipoQ receptor family member 3, progestin and adipoQ receptor family member III, RKTG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Paqr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Haemolysin-III related
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- epithelial cancer
- epithelial neoplasia
- cancer
- papillomatosis
- benign neoplasia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- hepatic steatosis
role in cell
- production in
- proliferation
- binding in
- signaling in
- differentiation
- development
- migration
- sprouting
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Paqr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAP kinase activity
- negative regulation of neuron projection development
- protein localization in Golgi apparatus
- negative regulation of protein phosphorylation
- negative regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity