HDAC11 Gene Summary [Human]
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
Details
| Type | Protein Coding |
| Official Symbol | HDAC11 |
| Official Name | histone deacetylase 11 [Source:HGNC Symbol;Acc:HGNC:19086] |
| Ensembl ID | ENSG00000163517 |
| Bio databases IDs | |
| Aliases | histone deacetylase 11 |
| Synonyms | HD11, histone deacetylase 11, MGC27683 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HDAC11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- linear amide carbon-nitrogen bond hydrolase
- histone deacetylase
- transcription factor binding
- protein binding
- Arginase-like and histone-like hydrolases
Pathways
Biological processes and signaling networks where the HDAC11 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Bladder Cancer Signaling
- Calcium Signaling
- Cell Cycle: G1/S Checkpoint Regulation
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of NFAT in Cardiac Hypertrophy
- Small Cell Lung Cancer Signaling
- Telomerase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- neoplasia
- epithelial cancer
- liver cancer
- angioimmunoblastic T-cell lymphoma
- enteropathy-associated T-cell lymphoma
- organismal death
- relapsed peripheral T-cell lymphoma
- peripheral T-cell lymphoma
role in cell
- expression in
- apoptosis
- production in
- development
- sphere formation
- organization
- unfolding
- killing by
- ubiquitination in
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HDAC11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte development
- chromatin organization
- regulation of gene expression, epigenetic
Cellular Component
Where in the cell the gene product is active
- nucleus
- histone deacetylase complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase activity