METAP1 Gene Summary [Human]
Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Involved in platelet aggregation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | METAP1 |
| Official Name | methionyl aminopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:15789] |
| Ensembl ID | ENSG00000164024 |
| Bio databases IDs | |
| Aliases | methionyl aminopeptidase 1, Peptidase M |
| Synonyms | 1700029C17Rik, MAP1A, MetAP1A, methionyl aminopeptidase 1, mKIAA0094 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human METAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zf-MYND-like zinc finger, mRNA-binding
- Metallopeptidase family M24
- metalloexopeptidase
- methionine aminopeptidase, type I
- peptidase
- aminopeptidase
- protein binding
- APP_MetAP
- methionyl aminopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human METAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- proteolysis
- N-terminal protein amino acid modification
- protein maturation
- platelet aggregation
- peptidyl-methionine modification
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- methionyl aminopeptidase activity
- protein binding
- metal ion binding
- metalloexopeptidase activity
- metalloaminopeptidase activity
- aminopeptidase activity