RRAS Gene Summary [Human]
The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | RRAS |
| Official Name | RAS related [Source:HGNC Symbol;Acc:HGNC:10447] |
| Ensembl ID | ENSG00000126458 |
| Bio databases IDs | |
| Aliases | RAS related, Oncogene RRAS |
| Synonyms | p23, RAS related, related RAS viral (r-ras) oncogene, RRAS1, Rras predicted |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RRAS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- effector domain
- Ras subfamily of RAS small GTPases
- binding protein
- CAAX box
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- PXXP motif
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RRAS gene in human plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- Bladder Cancer Signaling
- Chemokine Signaling
- CNTF Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- NF-κB Signaling
- Oncostatin M Signaling
- PAK Signaling
- PDGF Signaling
- PEDF Signaling
- PPAR Signaling
- Prolactin Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- TGF-β Signaling
- Thyroid Cancer Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- experimental autoimmune encephalomyelitis
- hereditary disorder
- serous ovarian adenocarcinoma
- serous ovarian cancer
- Noonan syndrome
role in cell
- growth
- cell death
- phosphorylation in
- proliferation
- function
- formation
- morphology
- migration
- differentiation
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- caveolae-derived endocytic vesicles
- focal adhesions
- Plasma Membrane
- endosomes
- cytosol
- recycling endosomes
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RRAS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukocyte differentiation
- regulation of protein kinase B signaling cascade
- regulation of ERK1 and ERK2 cascade
- Schwann cell migration
- positive regulation of vasculogenesis
- Ras protein signal transduction
- negative regulation of Schwann cell migration
- positive regulation of endothelial cell migration
- face morphogenesis
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding