TRIM29 Gene Summary [Human]
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM29 |
| Official Name | tripartite motif containing 29 [Source:HGNC Symbol;Acc:HGNC:17274] |
| Ensembl ID | ENSG00000137699 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 29, tripartite motif protein TRIM29, ataxia-telangiectasia group D-associated protein |
| Synonyms | 1110047J21Rik, 2810431N19Rik, 4732461M22Rik, ATDC, tripartite motif-containing 29 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- acetylation site
- B-box-type zinc finger superfamily
- B-box zinc finger
- p53 binding
- protein binding
- Outer membrane protein (OmpH-like)
- identical protein binding
Pathways
Biological processes and signaling networks where the TRIM29 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- epithelial cancer
- abdominal cancer
- epithelial neoplasia
- cancer
- tumorigenesis
- metastasis
- digestive system cancer
- colorectal cancer
- infection by HIV-1
role in cell
- expression in
- production in
- phosphorylation in
- degradation in
- migration
- apoptosis
- processing in
- survival
- colony formation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- Nucleus
- intermediate filaments
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM29 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of protein localization to nucleus
- innate immune response
Cellular Component
Where in the cell the gene product is active
- adherens junction
- lysosome
Molecular Function
What the gene product does at the molecular level
- p53 binding
- identical protein binding
- zinc ion binding
- protein binding